[SEMİNER] Computational Modeling of Low-Density Lipoprotein Transport in Human Coronary Arteries: Implications for Atherosclerosis

Tarih: 22.05.2012
Yer: Kandilli

Abstract: Coronary heart disease is the leading cause of death in the developed nations. It is the end result of atherosclerotic plaque formation in the coronary arteries. Accumulation of low-density lipoprotein (LDL) in arterial walls is believed to be the main initiator of atherosclerotic plaque formation. In this talk, the mechanisms governing the LDL transport from the artery lumen into the arterial wall will be explained. A coupled blood-wall mass transport model of LDL that realistically takes into account the role of endothelium and the effects of flow conditions on the endothelial cells will be presented. The application of this model to real patients will be discussed and potential correlations between LDL concentration and plaque formation will be quantified. Case studies involving 60 patients’ coronary arteries will be presented.

About the Speaker: Dr. Ufuk Olgaç is currently a post-doctoral researcher at Koç University in Istanbul. He obtained his B.Sc. degree from the Middle East Technical University (METU) in Ankara and M.Sc. degree from Koç University in Istanbul, both in mechanical engineering. He received his Ph.D. from the Swiss Federal Institute of Technology Zurich (ETHZ) in Switzerland with a thesis on the computational modeling of the coronary artery biofluidics. Dr. Olgaç is a member of the European Mechanics Society (EUROMECH) and he regularly participates in conferences on biomedical engineering and computational modeling of biological flows. He has been actively involved in research for the past 10 years on computational fluid dynamics (CFD) with focus on modeling biomedical flows. His interest is the convergence of engineering, biological and medical research to address clinically relevant needs related to the cardiovascular and respiratory systems.

Computational Modeling of Low-Density 

Lipoprotein Transport in Human Coronary Arteries: 
Implications for Atherosclerosis

  Dr. Ufuk Olgaç

Koç University, Istanbul

22 May 2012 (Tuesday);

15.00 – 17.00

@ Room AZ-19, BME-TAM Bldg, 

Bogazici Kandilli Campus,