Anodized Nanotubular Titanium as a Bone Anchored Prosthesis and the Effect of Electrical Stimulation

Tarih: 08.12.2015
Yer: Boğaziçi Üniversitesi Kandilli Rasathanesi

~~Anodized Nanotubular Titanium as a Bone Anchored Prosthesis and the Effect of Electrical Stimulation
Batur ERCAN, Ph.D.
Instructor, Metallurgical and Materials Engineering, Middle East Technical University
About the Seminar:
It is estimated that there are more than 500,000 amputees living in Turkey, and the currently used stump-socket based prosthesis have been the only means for artificial limb attachment to these patients. To improve the mobility of these amputee patients, the next generation implants need to be designed to possess bone-anchored components, directly transferring the load to the bone via a skin-penetrating abutment. Although bone-anchoring approach has significant advantages over the socket-based prosthesis, it suffers from high rate of infection at the skin-protruding surface, bone loss and bone fracture; making it a risky choice both for the patients and the surgeons.
This seminar will focus on using nanotechnology driven implants for orthopedic applications, specifically tailored towards bone-anchored implants. In order to improve the cytocompatibility properties of orthopedic implants, an anodization approach has been used to create nanotubular titanium surfaces. By synergistic combinations of biophysical cues (i.e. electrical stimulation) and altering scaffold surface feature size to nanometer regime, bone cell functions were maximized, while limiting the proliferation of scar tissue forming cells. Specifically, through decreasing the surface feature size of currently used titanium implants to 20nm, and without referring to any antibiotics, a five folds decrease in bacterial colonization was achieved. Importantly, the coupled approach of using electrical stimulation and nanofeatured surface topography gave the best tissue response in our studies.
Translatable knowledge from this work will broadly impact the field of nanobiomaterials and the implications will have a profound influence on the design and application of orthopedic implants.
 About the Speaker:
İsmail Dr Batur Ercan is a lecturer at Metallurgical and Materials Engineering at Middle East Technical University. Previously, he worked as a Product Innovation R&D engineer at Alvimedica Inc. focusing on novel CoCr based stents for renal applications. He was a postdoctoral Research Associate of Chemical Engineering at Northeastern University, working with Dr. Thomas Webster on nanobiomaterials for bone, ligament and skin tissue engineering. Prior to this position, he was a research fellow at Harvard Medical School under the mentorship of Dr. Mehmet Toner and specialized on microfluidic isolation of white blood cells from whole blood. He obtained his Ph.D degree at Brown University in Biomedical Engineering, and his M.S degree at Purdue University in Materials Engineering. His overarching academic goal is the incorporation of nanotechnology into regenerative medicine; in particular using nanophase materials to promote tissue regeneration. As a part of this process, he is integrating fundamental materials science concepts with biological principles to improve currently used biomaterials to heal damaged tissues.